Pharmaceutical Sciences CD [Computer file]

A CD-ROM containing over 160 papers from leading journals in the Pharmaceutical Sciences, issued as an introduction to Wiley resources in the subject. Contents listing includes selected content only.

[Archive der Pharmazie] Synthesis of tyrosinase inhibitory Kojic Acid derivative -- Novel Pirfenidone Analogues: Synthesis of Pyridin-2-ones for the Treatment of Pulmonary Fibrosis -- Potent Inhibitory Effects of Resveratrol Derivatives on progression of Prostate Cancer Cells -- Random Chemistry as a New Tool for the Generation of Small-Compound Libraries -- Rhodopsin: A Structural Primer for G-Protein Coupled Receptors.

[Biomedical Chromatography] A review of chromatographic methods for the assessment of phospholipids in biological samples -- Comprehensive multi-dimensional liquid chromatographic separation in biomedical and pharmaceutical analysis: a review -- Applicability of bioanalysis of multiple analytes in drug discovery and development: review of select case studies including assay development considerations -- Some remarks on characterization and application of stationary phases for RP-HPLC determination of biologically important compounds -- Analysis of five HMG-CoA reductase inhibitors - atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new method for use in pharmaceutical formulations analysis and in vitro metabolism studies.

[Biometrical Journal] Sample Size Recalculation in Internal Pilot Study Designs: A Review -- A Regulatory View on Adaptive/Flexible Clinical Trial Design -- An Overview of Statistical Approaches for Adaptive Designs and Design Modifications -- Application of Adaptive Designs - a Review -- FDA's Critical Path Initiative: A Perspective on Contributions of Biostatistics.

[Biopharmaceutics & Drug Disposition] Drug Disposition in Three Dimensions: An Update on Stereoselectivity in Pharmacokinetics -- Profiling In Vitro Drug Release from Subcutaneous Implants: A Review of Current Status and Potential Implications on Drug Product Development -- Apparent Active Transport of MDMA is not Mediated by P-glycoprotein: A Comparison with MDCK and Caco-2 Monolayers -- Resveratrol is Efficiently Glucuronidated by UDPGlucuronosyltransferases in the Human Gastrointestinal Tract and in Caco-2 Cells -- In Vitro Metabolism of Ciclesonide in Human Lung and Liver Precision-cut Tissue Slices.

[Biotechnology Journal] Manufacturing of recombinant therapeutic proteins in microbial systems -- Antimalarial drugs - host targets (re)visited -- Cancer immunotherapy -- Electric field driven jetting: an emerging approach for processing living cells -- Essential fatty acids: biochemistry, physiology and pathology.

[Cell Biochemistry and Function] A central role of eNOS in the protective effect of wine against metabolic syndrome -- Antioxidative and anti-diabetic effects of amaranth (Amaranthus esculantus) in streptozotocin-induced diabetic rats -- Tissue factor upregulation drives a thrombosis-inflammation circuit in relation to cardiovascular complications -- Investigation of protein oxidation and lipid peroxidation in patients with rheumatoid arthritis -- Role of fatty acids in the transition from anaerobic to aerobic metabolism in skeletal muscle during exercise.

[Chemistry and Biodiversity] A Broad Diversity of Volatile Carboxylic Acids, Released by a Bacterial Aminoacylase from Axilla Secretions, as Candidate Molecules for the Determination of Human-Body Odor Type -- Infrared Spectroscopy as a Tool for Chemotaxonomic Investigations within the Achillea millefolium Group -- 5-(Pyrrolidin-2-yl)-1H-tetrazole and 5-[(Pyrrolidin-2-yl)methyl]-1Htetrazole: Proline Surrogates with Increased Potential in Asymmetric Catalysis -- Synthesis and Biological Evaluation of New Quinazoline and Cinnoline Derivatives as Potential Atypical Antipsychotics -- DNA Containing Side Chains with Terminal Triple Bonds: Base-Pair Stability and Functionalization of Alkynylated Pyrimidines and 7-Deazapurines.

[Contrast Media and Molecular Imaging] First in vivo MRI assessment of a self-assembled metallostar compound endowed with a remarkable high field relaxivity -- Cellular labeling with Gd(III) chelates: only high thermodynamic stabilities prevent the cells acting as 'sponges' of Gd3+ ions -- Comparative study of the physicochemical properties of six clinical low molecular weight gadolinium contrast agentsy -- An HPLC/mass spectrometry platform for the development of multimodality contrast agents and targeted therapeutics: prostate-specific membrane antigen small molecule derivatives -- Pharmacokinetic and in vivo evaluation of a self-assembled gadolinium(III)-iron(II) contrast agent with high relaxivity.

[Drug Development Research] Biopolymer Albumin for Diagnosis and in Drug Delivery -- The Clinical Pharmacology of Therapeutic Monoclonal Antibodies -- Targeted Nanoparticles for Detecting and Treating Cancer -- Commercial Manufacturing Scale Formulation and Analytical Characterization of Therapeutic Recombinant Antibodies -- The Medicinal Chemistry of Tea.

[Journal of Applied Toxicology] -- A Good Practice Guide to the Administration of Substances and Removal of Blood, Including Routes and Volumes -- Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast -- A clinical flow cytometric biomarker strategy: validation of peripheral leukocyte phospholipidosis using Nile red -- Toxicology of fluoroacetate: a review, with possible directions for therapy research -- Hair analysis by GC/MS/MS to verify abuse of drugs.

[Journal of Mass Spectrometry] Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology -- The Orbitrap: a new mass spectrometer -- Structurally diagnostic ion/molecule reactions: class and functional-group identification by mass spectrometry -- Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry -- In vivo metabolite detection and identification in drug discovery via LC-MS/MS with data-dependent scanning and postacquisition data mining.

[Journal of Molecular Recognition] Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003 -- Survey of the year 2004 commercial optical biosensor literature -- Isothermal titration calorimetry and differential scanning calorimetry as complementary tools to investigate the energetics of biomolecular recognition -- Expression of heterologous proteins in Pichia pastoris: a useful experimental tool in protein engineering and production -- Advances in membrane receptor screening and analysis.

[Journal of Pharmaceutical Sciences] Analytical Techniques for Quantification of Amorphous / Crystalline Phases in Pharmaceutical Solids -- Cell Adhesion Molecules for Targeted Drug Delivery -- Enzymes Involved in the Bioconversion of Ester-Based Prodrugs -- Formulation Considerations for Proteins Susceptible to Asparagine Deamidation and Aspartate Isomerization -- Effect of Food Intake on the Oral Absorption of Poorly Water-Soluble Drugs: In Vitro Assessment of Drug Dissolution and Permeation Assay System.

[Molecular Nutrition and Food Research] The differential role of prostaglandin E2 receptors EP3 and EP4 in regulation of fever -- Chemistry and biology of vitamin E -- Food allergy -- Hypercholesterolemia and inflammation in atherogenesis: Two sides of the same coin -- Tea, obesity, and diabetes.

[Pharmaceutical Statistics] Review of guidelines and literature for handling missing data in longitudinal clinical trials with a case study -- Requiring 'independent' statistical analyses for industry sponsored trials? -- Adaptive designs for pivotal trials: discussion points from the PSI Adaptive Design Expert Group -- Adapting the sample size planning of a phase III trial based on phase II data -- Methodological issues with adaptation of clinical trial design.

[Pharmacoepidemiology and Drug Safety: An International Journal] Results from a rosuvastatin historical cohort study in more than 45 000 Dutch statin users, a PHARMO Study -- PharmDCardiovascular risk of selective cyclooxygenase-2 inhibitors and other non-aspirin non-steroidal anti-inflammatory medications -- A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience -- MDFDA drug prescribing warnings: is the black box half empty or half full? -- Sensitivity analysis and external adjustment for unmeasured confounders in epidemiologic database studies of therapeutics.

[Phytotherapy Research] The Efficacy of Silybum marianum (L.) Gaertn. (Silymarin) in the Treatment of Type II Diabetes: A Randomized, Double-blind, Placebo-controlled, Clinical Trial -- Potential Synergism of Natural Products in the Treatment of Cancer -- Antioxidant Activities of Some Lamiaceae Plant Extracts -- A Review of the Bioactivity and Potential Health Benefits of Peppermint Tea (Mentha piperita L.) -- Anti-influenza Agents from Plants and Traditional Chinese Medicine.

[QSAR and Combinational Science] Data and Graph Mining in Chemical Space for ADME and Activity Data Sets -- Dock around the Clock - Current Status of Small Molecule Docking and Scoring -- On Selection of Training and Test Sets for the Development of Predictive QSAR models -- Current Status of Combinatorial and High-Throughput Methods for Discovering New Materials and Catalysts -- The Application of Microreactors in Combinatorial Chemistry.

[Rapid Communications in Mass Spectrometry] Phosphopeptide quantitation using amine-reactive isobaric tagging reagents and tandem mass spectrometry: application to proteins isolated by gel electrophoresis -- The use of recently described ionisation techniques for the rapid analysis of some common drugs and samples of biological origin -- Desorption electrospray ionization mass spectrometry: direct toxicological screening and analysis of illicit Ecstasy tablets -- Desorption electrospray ionization mass spectrometry for the analysis of pharmaceuticals and metabolites -- Development of a multi-target screening analysis for 301 drugs using a QTrap liquid chromatography/tandem mass spectrometry system and automated library searching.

[Statistics in Medicine] A Simple Method of Sample Size Calculation for Linear and Logistic Regression -- Tutorial in Biostatistics : An Introduction to Hierarchical Linear Modelling -- Dichotomizing continuous predictors in multiple regression: a bad idea -- Statistical evaluation of biomarkers as surrogate endpoints: a literature review -- Tutorial in Biostatistics Propensity Score Methods for Bias Reduction in the Comparison of a Treatment to a Non-Randomized Control.

[The Quality Assurance Journal] Bioanalytical Quality Assurance: Concepts and Concerns -- Technology-Driven Forms of Quality Improvement and Technical Evolution -- Development of a Professional Quality Assurance Society - The SQA Model -- International Marketing Applications According to the ICH CTD Format: Comparison of Structure and Document Requirements -- The Role of the Study Director in GLP.

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