| 000 | 04168nam a22006255i 4500 | ||
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| 001 | 978-3-319-60192-2 | ||
| 003 | DE-He213 | ||
| 005 | 20201217111716.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 170914s2017 gw | s |||| 0|eng d | ||
| 020 |
_a9783319601922 _9978-3-319-60192-2 |
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| 024 | 7 |
_a10.1007/978-3-319-60192-2 _2doi |
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_aMFN _2bicssc |
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_aMED107000 _2bisacsh |
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_aMFN _2thema |
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_a611.01816 _223 |
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_a599.935 _223 |
| 245 | 1 | 0 |
_aGenome Editing in Neurosciences _h[electronic resource] / _cedited by Rudolf Jaenisch, Feng Zhang, Fred Gage. |
| 250 | _a1st ed. 2017. | ||
| 264 | 1 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2017. |
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| 300 |
_aXI, 123 p. 16 illus. in color. _bonline resource. |
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| 336 | _btxt | ||
| 337 | _bc | ||
| 338 | _bcr | ||
| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 |
_aResearch and Perspectives in Neurosciences, _x0945-6082 |
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| 500 | _aIT Carlow ebook | ||
| 505 | 0 | _aIntroduction -- In vitro modeling of complex neurological diseases -- Aquatic model organisms in neurosciences : the genome editing revolution -- Genome-wide genetic screening in the mammalian CNS -- CRISPR/Cas9-mediated Knockin and Knockout in Zebrafish -- Dissecting the role of synaptic proteins with CRISPR -- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer -- Neuroscience research using non-human primate models and genome editing -- Multiscale genome engineering: Genome-wide screens and targeted approaches -- Using Genome Engineering to Understand Huntington's Disease -- Therapeutic gene editing in muscles and muscle stem cells. | |
| 506 | 0 | _aOpen Access | |
| 520 | _aThis book is open access under a CC BY 4.0 license. Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders. | ||
| 650 | 0 |
_aHuman genetics. _94480 |
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| 650 | 0 |
_aNeurosciences. _953748 |
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| 650 | 0 |
_aBiomedical engineering. _91725 |
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| 650 | 1 | 4 |
_aHuman Genetics. _0https://scigraph.springernature.com/ontologies/product-market-codes/B12008 _94480 |
| 650 | 2 | 4 |
_aNeurosciences. _0https://scigraph.springernature.com/ontologies/product-market-codes/B18006 _953748 |
| 650 | 2 | 4 |
_aBiomedical Engineering/Biotechnology. _0https://scigraph.springernature.com/ontologies/product-market-codes/B24000 _997926 |
| 700 | 1 |
_aJaenisch, Rudolf. _9104116 |
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| 700 | 1 |
_aZhang, Feng. _9104117 |
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| 700 | 1 |
_aGage, Fred. _9104118 |
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| 710 | 2 |
_aSpringerLink (Online service) _930940 |
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| 773 | 0 | _tSpringer Nature eBook | |
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_iPrinted edition: _z9783319601915 |
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_iPrinted edition: _z9783319601939 |
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_iPrinted edition: _z9783319868011 |
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_aResearch and Perspectives in Neurosciences, _x0945-6082 _9104119 |
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| 856 | 0 |
_ySend a message to library staff if access to this online resource is unavailable _uhttps://tinyurl.com/y2hljxwd |
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| 856 | 4 | 0 |
_yLink to Springer open access ebook _uhttps://doi.org/10.1007/978-3-319-60192-2 |
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